The main adverse health effects are associated with exposure to heavy metals such as arsenic, cadmium, lead and mercury. These metals have been widely studied and their effects on human health regularly revised by international organization such as WHO. Adverse health effects of heavy metals have been known for a long time, exposure to heavy metals increasing in some areas, especially in less developed countries. In particular, the public should be aware of exposure to heavy metals via drinking water. Water is the great, compound in the lifecycle because nobody can live without water. Humans, animals and plants need water in abundance, as water represents about 60% of their bodies. According to organisms need water so that they can carry out vital operations to the fullest. Water is working on an analysis of the nutrients in the bodies of living organisms through its distribution to various organs of the body, and converting it to energy or important materials for bodies growth. Water is needed to get rid of waste products as well. It is worth mentioning that the man cannot live more than three days without water. The presence of heavy metals is probably the most common water problem facing by consumers. Heavy metals (such as Arsenic, Zinc, Iron, Manganese, Aluminum, Cadmium, Lead and others) cause many health problems if they are found in drinking water at concentrations higher than permitted. So, the aim of this review to highlight the sources of heavy metals in drinking water and its dangerous effects against human health.